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AIC-292

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Category Human immunodeficiency Virus (HIV)
CAS 1187917-12-9
Description AIC-292 is a potent and selective inhibitor of HIV-1 nonnucleoside reverse transcriptase. It inhibits wild-type HIV-1 laboratory strains at low nanomolar concentrations. AIC-292 displays potent antiviral in vivo efficacy in a mouse xenograft model.
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Product Information

Synonyms AIC-292|LE2GYT0UFH|UNII-LE2GYT0UFH|1187917-12-9|AIC292|SCHEMBL1526038|AIC 292|SB17103|HY-19925|CS-0016931|1-((1-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1H-pyrazol-3-yl)carbonyl)-4-imidazolidinone|1-[1-(3-chloro-4-fluoro-phenyl)-5-(3-chloro-5-fluoro-phenyl)pyrazole-3-carbonyl]imidazolidin-4-one|1-{[1-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1H-pyrazol-3-yl]carbonyl}imidazolidin-4-one|4-Imidazolidinone, 1-((1-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1H-pyrazol-3-yl)carbonyl)-
Molecular Weight 437.23
Molecular Formula C19H12Cl2F2N4O2
Canonical SMILES C1C(=O)NCN1C(=O)C2=NN(C(=C2)C3=CC(=CC(=C3)Cl)F)C4=CC(=C(C=C4)F)Cl
Purity ≥95%
Solubility In vitro:
10 mM in DMSO
Appearance A crystalline solid
Storage -20°C
Complexity 645
Exact Mass 436.0305374
Target HIV
XLogP3-AA 4

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