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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
AG 1478 hydrochloride
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| Category | Hepatitis C Virus (HCV) |
| CAS | 170449-18-0 |
| Description | The hydrochloride salt form of AG 1478, which has been found to be an epidermal growth factor receptor tyrosine kinase inhibitor. |
Product Information
| Synonyms | AG 1478 hydrochloride; AG1478 hydrochloride; AG-1478 hydrochloride; N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine hydrochloride |
| Molecular Weight | 352.22 |
| Molecular Formula | C16H14ClN3O2.HCl |
| Canonical SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC.Cl |
| InChI | InChI=1S/C16H14ClN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H |
| InChIKey | WDJDYIUSDDVWKB-UHFFFAOYSA-N |
| Boiling Point | 458.5ºC at 760mmHg |
| Flash Point | 231.1ºC |
| Purity | ≥98% by HPLC |
| Density | 1.337g/cm3 |
| Solubility | DMSO: Soluble |
| Appearance | Cream Solid |
| Storage | Store at -20°C |
| Exact Mass | 351.054138 |
| In Vitro | AG-1478 is irreversible for growth regulation of human lung (A549) and prostate (DU145) cancer cell lines. AG-1478 seems to be more effective at lower concentrations, but is unable to completely inhibit growth of A549 cells. Inhibition of EGFR by specific tyrosine kinase inhibitor AG-1478 significantly decreases the angiotensin II-mediated synthesis of TGF-β and fibronectin by cardiac fibroblasts. EGFR is pharmacologically inhibited by small-molecule inhibitor AG-1478 with IC50 of 4 nM. |
| In Vivo | Administration of AG-1478 significantly reduces myocardial inflammation, fibrosis, Apoptosis, and dysfunction in both two obese mouse models. |
| PSA | 56.27000 |
| Target | EGFR: 3 nM(IC50); HCV; EMCV |
| Vapor Pressure | 1.37E-08mmHg at 25°C |
