AEBSF HCl

Category	Influenza Virus
CAS	30827-99-7
Description	AEBSF is a water-soluble, irreversible serine protease inhibitor that inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.

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Product Information

Synonyms	4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride; AEBSF hydrochloride; AEBSF
IUPAC Name	4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride
Molecular Weight	239.69
Molecular Formula	C8H11ClFNO2S
Canonical SMILES	C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
InChI	InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChIKey	WRDABNWSWOHGMS-UHFFFAOYSA-N
Boiling Point	292.5°C at 760 mmHg
Melting Point	175-177 °C
Flash Point	130.7°C
Purity	98%
Solubility	In Vitro: DMSO : 125mg/mL(521.51mM;Need ultrasonic) H2O : 100 mg/mL(417.21 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:Saline Solubility: 100 mg/mL (417.21 mM); Clear solution; Need ultrasonic 2.Add each solvent one by one:10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline Solubility: ≥ 2.08 mg/mL (8.68 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90% (20% SBE-β-CD in saline) Solubility: ≥ 2.08 mg/mL (8.68 mM); Clear solution 4.Add each solvent one by one:10% DMSO >> 90% corn oil Solubility: ≥ 2.08 mg/mL (8.68 mM); Clear solution
Appearance	White to off-white (Solid)
Storage	Store in a dry and well-ventilated place.
Animal Admin	Mice injected with parasites are randomly assigned to one of the treatment groups according to the treatment given: without drugs (control group), vehicle alone (vehicle control group), pyrimethamine alone at different doses, LY311727 alone at different doses, AEBSF alone at different doses or AEBSF 76.8 mg/kg plus pyrimethamine 10 mg/kg. Mouse survival is monitored daily and continued in live mice until 15 days post-infection. The data shown represent the cumulative results.
Complexity	239
Exact Mass	239.018311
In Vitro	AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern.
In Vivo	AEBSF (76.8 mg/kg daily, i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model.
PSA	68.54000
Target	Thrombin; Influenza Virus; Ser/Thr Protease