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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Adefovir
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| Category | Hepatitis B Virus (HBV) |
| CAS | 106941-25-7 |
| Description | Used as an antiviral. |
Product Information
| Synonyms | P-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic Acid; 9-(2-Phosphonylmethoxyethyl)adenine; |
| IUPAC Name | 2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid |
| Molecular Weight | 273.19 |
| Molecular Formula | C8H12N5O4P |
| Canonical SMILES | C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N |
| InChI | InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16) |
| InChIKey | SUPKOOSCJHTBAH-UHFFFAOYSA-N |
| Boiling Point | 632.5±65.0 °C at 760 mmHg |
| Melting Point | >250 °C |
| Flash Point | 336.3±34.3 °C |
| Purity | > 95% |
| Density | 1.9±0.1 g/cm3 |
| Solubility | In Vitro: 0.1 M NaOH : 10 mg/mL (36.60 mM; ultrasonic and adjust pH to 10 with NaOH) H2O : 1 mg/mL (3.66 mM; ultrasonic and warming and heat to 60°C) |
| Appearance | Off-White to Light Brown Solid |
| Application | Phosphonic acids; adenine/analogs & derivatives; antiviral agents; reverse transcriptase inhibitors |
| Storage | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
| Complexity | 327 |
| Exact Mass | 273.062683 |
| Index Of Refraction | 1.769 |
| In Vitro | The phosphorylation of Adefovir occurred intracellularly and is carried out by host cellular enzymes. The diphosphorylated derivatives of Adefovir targeted the viral DNA polymerase and also acted as DNA chain terminators. |
| In Vivo | Adefovir achieves 60% oral bioavailability. Its half-life is 12-30 hours and Adefovir undergoes renal excretion without significant metabolites. In addition, Adefovir does not substantially affect the cytochrome P450 system. |
| PSA | 146.19000 |
| Target | HBV; DNA polymerase |
| Vapor Pressure | 0.0±2.0 mmHg at 25°C |
| XLogP3-AA | -2 |
