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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
Acriflavine-hydrochloride
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| Category | SARS-CoV |
| CAS | 69235-50-3 |
| Description | Acriflavine hydrochloride is a potent HIF-1 inhibitor, with antitumor activity. It also has antimicrobial and antiviral activities. Acriflavine hydrochloride is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2. |
Product Information
| Synonyms | Acriflavine hydrochloride|69235-50-3|Acriflavine (hydrochloride)|ACRIFLAVINE HCl|acridine-3,6-diamine;10-methylacridin-10-ium-3,6-diamine;chloride;trihydrochloride|MFCD00069039|Gonacrin|CHEMBL4594247|Acriflavine Hydrochloride BPC 63|BCP34400|AKOS015902555|BS-44178|D88307|Mixture of 3,6-Diamino-10-methylacridinium chloride and 3,6-acridinediamine Chromoflavine |
| Molecular Weight | 541.90 |
| Molecular Formula | C27H28Cl4N6 |
| Canonical SMILES | C[N+]1=C2C=C(C=CC2=CC3=C1C=C(C=C3)N)N.C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N.Cl.Cl.Cl.[Cl-] |
| Purity | ≥98% (HPLC) |
| Solubility | In Vitro: DMSO : 25mg/mL(46.13 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (4.61 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (4.61 mM); Clear solution |
| Appearance | White to off-white (Solid) |
| Storage | 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) |
| Complexity | 486 |
| Exact Mass | 576.112976 |
| Target | HIF/HIF Prolyl-Hydroxylase; Bacterial; SARS-CoV |
