-
Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
Ac-CoA Synthase Inhibitor 1
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| Category | Respiratory syncytial Virus (RSV) |
| CAS | 508186-14-9 |
| Description | Ac-CoA Synthase Inhibitor 1 is an anti-virus agent. |
Product Information
| Synonyms | 1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea |
| IUPAC Name | 1-(2,3-dithiophen-2-ylquinoxalin-6-yl)-3-(2-methoxyethyl)urea |
| Molecular Weight | 410.51 |
| Molecular Formula | C20H18N4O2S2 |
| Canonical SMILES | COCCNC(=O)NC1=CC2=C(C=C1)N=C(C(=N2)C3=CC=CS3)C4=CC=CS4 |
| InChI | InChI=1S/C20H18N4O2S2/c1-26-9-8-21-20(25)22-13-6-7-14-15(12-13)24-19(17-5-3-11-28-17)18(23-14)16-4-2-10-27-16/h2-7,10-12H,8-9H2,1H3,(H2,21,22,25) |
| InChIKey | CTPVNWVUAGMHEJ-UHFFFAOYSA-N |
| Boiling Point | 539.3±50.0 °C at 760 mmHg |
| Flash Point | 280.0±30.1 °C |
| Purity | ≥95% |
| Density | 1.4±0.1 g/cm3 |
| Solubility | In Vitro: DMSO : 31.25mg/mL(76.12 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20% SBE-β-CD in saline) Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90% corn oil Solubility: ≥ 2.5 mg/mL (6.09 mM); Clear solution |
| Appearance | Lyophilized Powder |
| Storage | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
| Complexity | 526 |
| Exact Mass | 410.087128 |
| Index Of Refraction | 1.691 |
| In Vitro | Ac-CoA Synthase Inhibitor1 inhibits cellular [14C]acetate uptake into both lipids and histones with an IC50 of 5 µM. Ac-CoA Synthase Inhibitor1 inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC50 of 6.8 µM. Ac-CoA Synthase Inhibitor1 inhibits HepG2 utilization of [14C]acetate for histone acetylation with IC50 of 5.5 µM. |
| Target | RSV |
| Vapor Pressure | 0.0±1.4 mmHg at 25°C |
| XLogP3-AA | 2.8 |
