ABT-072

Category	Hepatitis C Virus (HCV)
CAS	1132936-00-5
Description	ABT-072 is a potent and orally active non-nucleoside HCV NS5B polymerase inhibitor with EC50s of 1 nM and 0.3 nM for HCV GT1a and HCV GT1b, respectively.

Quotation Now

Synonyms	(E)-N-(4-(3-(tert-Butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxystyryl)phenyl)methanesulfonamide; Methanesulfonamide, N-[4-[(1E)-2-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]ethenyl]phenyl]-; N-(4-{(E)-2-[5-(2,4-Dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-2-methoxy-3-(2-methyl-2-propanyl)phenyl]vinyl}phenyl)methanesulfonamide
IUPAC Name	N-[4-[(E)-2-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]ethenyl]phenyl]methanesulfonamide
Molecular Weight	469.55
Molecular Formula	C24H27N3O5S
Canonical SMILES	CC(C)(C)C1=CC(=CC(=C1OC)C=CC2=CC=C(C=C2)NS(=O)(=O)C)N3C=CC(=O)NC3=O
InChI	InChI=1S/C24H27N3O5S/c1-24(2,3)20-15-19(27-13-12-21(28)25-23(27)29)14-17(22(20)32-4)9-6-16-7-10-18(11-8-16)26-33(5,30)31/h6-15,26H,1-5H3,(H,25,28,29)/b9-6+
InChIKey	XMZSTQYSBYEENY-RMKNXTFCSA-N
Purity	≥95%
Density	1.3±0.1 g/cm3
Solubility	Soluble in DMSO
Appearance	Solid Powder
Storage	Store at -20°C
Complexity	879
Exact Mass	469.167145
Index Of Refraction	1.625
In Vitro	ABT-072 is a non-nucleoside NS5B polymerase inhibitor with nanomolar potency in vitro against genotype 1a and 1b hepatitis C virus polymerases.
In Vivo	ABT-072 shows good PK properties, low plasma clearance and high oral bioavailabilit.
Target	NS5B polymerase
XLogP3-AA	3.6