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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Abacavir sulfate
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 216699-07-9 |
| Description | Abacavir is an antiviral analog of guanosine, inhibiting the reverse transcriptase of HIV type 1 with an IC50 value of 5.3 μM. |
Product Information
| Synonyms | 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)-, sulfate (2:1) |
| Molecular Weight | 384.4 |
| Molecular Formula | C14H18N6O·H2SO4 |
| Canonical SMILES | C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.OS(=O)(=O)O |
| InChI | InChI=1S/C14H18N6O.H2O4S/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21;1-5(2,3)4/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19);(H2,1,2,3,4)/t8-,10+;/m1./s1 |
| InChIKey | MBFKCGGQTYQTLR-SCYNACPDSA-N |
| Melting Point | >104 °C (dec.) |
| Purity | ≥98% |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Crystalline Solid |
| Storage | Store at -20°C |
| In Vitro | Abacavir monosulfate showed a dose-dependent growth inhibition on PC3 and LNCaP. |
| In Vivo | Abacavir monosulfate dose-dependently promoted thrombus formation. |
| Target | HIV; Reverse Transcriptase; Telomerase; Apoptosis |
