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Antiviral API
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Abacavir Sulfate (2:1)
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 188062-50-2 |
| Description | Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1. Abacavir is an analog of guanosine (a purine). Its target is the viral reverse transcriptase enzyme. |
Product Information
| Synonyms | 1592U89 |
| IUPAC Name | [(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol;sulfuric acid |
| Molecular Weight | 335.35 |
| Molecular Formula | C14H18N6O.1/2H2O4S |
| Canonical SMILES | C1CC1NC2=NC(=NC3=C2N=CN3C4CC(C=C4)CO)N.C1CC1NC2=NC(=NC3=C2N=CN3C4CC(C=C4)CO)N.OS(=O)(=O)O |
| InChI | InChI=1S/2C14H18N6O.H2O4S/c2*15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21;1-5(2,3)4/h2*1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19);(H2,1,2,3,4)/t2*8-,10+;/m11./s1 |
| InChIKey | WMHSRBZIJNQHKT-FFKFEZPRSA-N |
| Boiling Point | 636°C at 760 mmHg |
| Melting Point | 213-214 °C |
| Flash Point | 338.4°C |
| Purity | 95% |
| Density | 1.9±0.1 g/cm3 |
| Solubility | In Vitro: DMSO : 50 mg/mL(115.35 mM;Need ultrasonic) H2O : 33.33 mg/mL (76.89 mM; Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (5.77 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (5.77 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90% corn oil Solubility: ≥ 2.5 mg/mL (5.77 mM); Clear solution |
| Appearance | White to Off-White Solid |
| Storage | Store at RT |
| Complexity | 496 |
| Exact Mass | 670.27579815 |
| Index Of Refraction | 1.851 |
| In Vitro | Abacavir (15 and 150 μM, 0-120 h) sulfate inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines. In addition, it significantly reduces cell migration and inhibits cell invasion. |
| In Vivo | Abacavir (0-7.5 μg/mL, 100 μL, intrascrotal administration; 100 and 200 mg/kg, p.o.; 4 h) sulfate dose-dependently promoted thrombus formation. Abacavir (50 mg/kg/d; i.p.; 14 days) sulfate with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice. |
| PSA | 153.63000 |
| Target | Reverse Transcriptase; HIV; Telomerase; Apoptosis |
