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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
9-Carboxymethoxymethylguanine
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| Category | Herpes simplex Virus (HSV) |
| CAS | 80685-22-9 |
| Description | 9-Carboxymethoxymethylguanine is the main metabolite of Aciclovir, which is an orally active antiviral drug. |
Product Information
| Synonyms | 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]acetic Acid; Acyclovir Acid; CMMG; 2-((2-Amino-6-oxo-1H-purin-9(6H)-yl)methoxy)acetic acid; Acetic acid, 2-[(2-amino-3,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]- |
| IUPAC Name | 2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]acetic acid |
| Molecular Weight | 239.19 |
| Molecular Formula | C8H9N5O4 |
| Canonical SMILES | C1=NC2=C(N1COCC(=O)O)N=C(NC2=O)N |
| InChI | InChI=1S/C8H9N5O4/c9-8-11-6-5(7(16)12-8)10-2-13(6)3-17-1-4(14)15/h2H,1,3H2,(H,14,15)(H3,9,11,12,16) |
| InChIKey | MICNQLKUSOVNNG-UHFFFAOYSA-N |
| Boiling Point | 696.5±63.0°C at 760 mmHg |
| Melting Point | >224°C (dec.) |
| Flash Point | 375.0±33.7 °C |
| Purity | ≥95% |
| Density | 1.9±0.1 g/cm3 |
| Solubility | Soluble in Aqueous Acid (Slightly), DMSO (Slightly, Heated) |
| Appearance | Light Yellow to Light Brown Solid |
| Application | Antiviral Agents |
| Storage | Store at -20°C under inert atmosphere |
| Complexity | 371 |
| Exact Mass | 239.065460 |
| Index Of Refraction | 1.802 |
| In Vitro | Acyclovir is metabolized by the alcohol dehydrogenase (ADH) enzyme to Acyclovir aldehyde, and acyclovir aldehyde is subsequently metabolized by the aldehyde dehydrogenase (ALDH) enzyme to 9-Carboxymethoxymethylguanine (CMMG). |
| Target | HSV |
| Vapor Pressure | 0.0±2.3 mmHg at 25°C |
| XLogP3-AA | -1.6 |
