-
Antiviral API
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7-Deaza-2',3'-dideoxyguanosine
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 111869-49-9 |
| Description | 7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) is a 2',3'-dideoxynucleoside 5'-triphosphate, which can inhibit HIV-1 reverse transcriptase with a Ki of 25 nM. |
Product Information
| Synonyms | 2-Amino-7-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one; 7-Deaza-ddG; 2',3'-Dideoxy-7-Deazaguanosine; 7-Deaza-2',3'-dideoxy-D-guanosine; 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-3,7-dihydro-7-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]- |
| IUPAC Name | 2-amino-7-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-pyrrolo[2,3-d]pyrimidin-4-one |
| Molecular Weight | 250.25 |
| Molecular Formula | C11H14N4O3 |
| Canonical SMILES | C1CC(OC1CO)N2C=CC3=C2N=C(NC3=O)N |
| InChI | InChI=1S/C11H14N4O3/c12-11-13-9-7(10(17)14-11)3-4-15(9)8-2-1-6(5-16)18-8/h3-4,6,8,16H,1-2,5H2,(H3,12,13,14,17)/t6-,8+/m0/s1 |
| InChIKey | IRKZBFORRGBSAO-POYBYMJQSA-N |
| Melting Point | 228°C (dec.) |
| Purity | ≥97% by HPLC |
| Density | 1.75±0.1 g/cm3 (Predicted) |
| Solubility | Soluble in Methanol |
| Appearance | White to Off-white Crystalline Powder |
| Storage | Store at RT |
| Exact Mass | 345.07400 |
| PSA | 184.19000 |
| Target | HIV-1 |
