6-Azathymine

Category	Influenza Virus
CAS	932-53-6
Description	6-Azathymine, a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor, inhibits DNA biosynthesis and has antibacterial and antiviral activities.

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Synonyms	6-Methyl-1,2,4-triazine-3,5(2H,4H)-dione; 5-Methyl-6-azauracil; Azathymine; 6-Methyl-1,2,4-triazine-3,5-diol; 6-Methyl-1,2,4-triazine-3,5-dione; NSC 3426; 6-Methyl-as-triazine-3,5-(2H,4H)-dione; NSC 38620; 3,5-Dihydroxy-6-methyl-1,2,4-triazine
IUPAC Name	6-methyl-2H-1,2,4-triazine-3,5-dione
Molecular Weight	127.10
Molecular Formula	C4H5N3O2
Canonical SMILES	CC1=NNC(=O)NC1=O
InChI	InChI=1S/C4H5N3O2/c1-2-3(8)5-4(9)7-6-2/h1H3,(H2,5,7,8,9)
InChIKey	XZWMZFQOHTWGQE-UHFFFAOYSA-N
Melting Point	210-212°C
Purity	≥95%
Density	1.67±0.1 g/cm3
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid Powder
Storage	Store at RT
Complexity	196
Exact Mass	127.038177
Index Of Refraction	1.692
In Vitro	6-Azathymine is a competitive antagonist of the growth of Streptococcus faecalis and several other strains of microorganisms.
In Vivo	The administration of 6-Azathymine to the mouse leads to the urinary elimination not only of free Azathymine, but also of various metabolites of it.
PSA	78.61000
Target	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Bacterial; Influenza Virus
XLogP3-AA	-0.3