5-Hydroxy Valproic acid-[d7] sodium salt

Category	Human immunodeficiency Virus (HIV)
CAS	1189994-89-5
Description	5-Hydroxy Valproic acid-[d7] sodium salt is the labelled analogue of 5-Hydroxy Valproic acid sodium salt, which is a metabolite of Valproic Acid.

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Product Information

Synonyms	5-Hydroxy Valproic acid-d7 sodium salt; 5-OH-VPA-d7; 5-Hydroxy-2-(propyl-d7)pentanoic Acid; 2-(Propyl-d7)-5-hydroxypentanoic Acid Sodium Salt; 2-N-(Propyl-d7)-5-hydroxypentanoic Acid Sodium Salt; rac 5-Hydroxy Valproic Acid-d7 Sodium Salt
IUPAC Name	sodium;3,3,4,4,5,5,5-heptadeuterio-2-(3-hydroxypropyl)pentanoate
Molecular Weight	189.24
Molecular Formula	C8H8D7NaO3
Canonical SMILES	CCCC(CCCO)C(=O)[O-].[Na+]
InChI	InChI=1S/C8H16O3.Na/c1-2-4-7(8(10)11)5-3-6-9;/h7,9H,2-6H2,1H3,(H,10,11);/q;+1/p-1/i1D3,2D2,4D2;
InChIKey	CSZWWXWOLIYBAB-MDVNJVHASA-M
Purity	≥95%; ≥99% atom D
Solubility	Soluble in Methanol (Slightly, Sonicated)
Appearance	White to Pale Yellow Solid
Storage	Store at -20°C under inert atmosphere
In Vitro	Valproic acid (VPA) (0-15 mM; 24 and 72 h) inhibits Hela cell growth in a dose- and time- dependent manner. Valproic acid (10 mM; 24 h) significantly attenuates the activities of total, cytosol and nuclear HDACs. Valproic acid (0-15 mM; 24 h) induces a G1 phase arrest at 1-3 mM and a G2/M phase arrest at 10 mM, and increases the percentage of sub-G1 cells in HeLa cells. Valproic acid also induces necrosis, Apoptosis and Lactate dehydrogenase (LDH) release. Valproic acid (0-20 mM; 24 h) activates Tcf/Lef-dependent transcription and synergizes with lithium. Valproic acid (0-5 mM; 0-18 h) increases β-catenin levels in Neuro2A cells. Valproic acid (0-2 mM; 0-24 h) stimulates phosphorylation of AMPK and ACC in hepatocytes. Valproic acid (0-10 mM; 2 days) induces Notch1 signaling and morphologic differentiation, suppresses production of NE tumor markers in SCLC cells.
In Vivo	Valproic acid (VPA) (500 mg/kg; i.p.; daily for 12 days) inhibits tumor angiogenesis in mice transplanted with Kasumi-1 cells. Valproic acid (350 mg/kg; i.p.; once) enhances social behavior in rats. Valproic acid (0.26% (w/v); p.o. via drinking water; 14 days) decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice without hepatotoxicity.
Target	HDAC; Autophagy; Mitophagy; HIV; Notch; Endogenous Metabolite