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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid methyl ester
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| Category | Cytomegalovirus (CMV) |
| CAS | 391680-92-5 |
| Description | pUL89 Endonuclease-IN-1 (Compound 13d) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC50 value of 0.88 μM and has antiviral activitiy. |
Product Information
| IUPAC Name | methyl 5-hydroxy-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxylate |
| Molecular Weight | 252.25 |
| Molecular Formula | C10H8N2O4S |
| Canonical SMILES | COC(=O)C1=C(C(=O)NC(=N1)C2=CC=CS2)O |
| InChI | InChI=1S/C10H8N2O4S/c1-16-10(15)6-7(13)9(14)12-8(11-6)5-3-2-4-17-5/h2-4,13H,1H3,(H,11,12,14) |
| InChIKey | QAIMSDCSXBBWEK-UHFFFAOYSA-N |
| Purity | ≥98% (HPLC) |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| In Vitro | pUL89 Endonuclease-IN-1 (compound 13d) is strongly inhibited pUL89-C with the values of IC500.88μM. pUL89 Endonuclease-IN-1 reveals excellent aqueous solubility, plasma stability, and Metabolic stability in vitro ADME. pUL89 Endonuclease-IN-1 displays moderately permeability in the PAMPA. |
| Target | IC50:0.88μM (pUL89-C) |
