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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
4'-Ethynyl-2'-deoxyadenosine
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 306305-07-7 |
| Description | 4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity. |
Product Information
| Synonyms | (2R,3S,5R)-5-(6-aminopurin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol |
| IUPAC Name | (2R,3S,5R)-5-(6-aminopurin-9-yl)-2-ethynyl-2-(hydroxymethyl)oxolan-3-ol |
| Molecular Weight | 275.26 |
| Molecular Formula | C12H13N5O3 |
| Canonical SMILES | C#CC1(C(CC(O1)N2C=NC3=C(N=CN=C32)N)O)CO |
| InChI | InChI=1S/C12H13N5O3/c1-2-12(4-18)7(19)3-8(20-12)17-6-16-9-10(13)14-5-15-11(9)17/h1,5-8,18-19H,3-4H2,(H2,13,14,15)/t7-,8+,12+/m0/s1 |
| InChIKey | HMIGVKANVVLEOA-JOAULVNJSA-N |
| Boiling Point | 202.4±30.0 °C at 760 mmHg |
| Flash Point | 91.4±16.2 °C |
| Purity | ≥95% |
| Density | 1.2±0.1 g/cm3 |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid Powder |
| Storage | Store lyophilized at -20°C, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20°C and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| Exact Mass | 136.032440 |
| Index Of Refraction | 1.560 |
| Target | HIV; Reverse Transcriptase |
| Vapor Pressure | 0.2±0.4 mmHg at 25°C |