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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
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- HIV Protease
- Human immunodeficiency Virus (HIV)
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- Rabies virus (RABV)
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- West Nile virus
- Antiviral intermediates
3,4-Dimethoxycinnamic acid, predominantly trans
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| Category | Virus Protease |
| CAS | 2316-26-9 |
| Description | 3,4-Dimethoxycinnamic acid isolated from the leaves of Phyllostachys heterocycla. |
Product Information
| Synonyms | (E)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid |
| IUPAC Name | (E)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid |
| Molecular Weight | 208.21 |
| Molecular Formula | C11H12O4 |
| Canonical SMILES | COC1=C(C=C(C=C1)C=CC(=O)O)OC |
| InChI | InChI=1S/C11H12O4/c1-14-9-5-3-8(4-6-11(12)13)7-10(9)15-2/h3-7H,1-2H3,(H,12,13)/b6-4+ |
| InChIKey | HJBWJAPEBGSQPR-GQCTYLIASA-N |
| Boiling Point | 367.4 °C at 760 mmHg |
| Melting Point | 181-183°C(lit.) |
| Flash Point | 144.0±17.2 °C |
| Purity | 98.5 % |
| Density | 1.203 g/cm3 |
| Solubility | In Vitro: DMSO : 50 mg/mL(240.14 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90% corn oil Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution |
| Appearance | White powder |
| Application | 3,4-Dimethoxycinnamic Acid is a Cinnamic Acid (C442030) derivative,used in the synthesis of amides and esters through coupling reactions involving carboxylic acids and amines and N-methylation of amides and O-methylation of carboxylic acids. |
| Storage | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
| Complexity | 237 |
| Exact Mass | 208.07355886 |
| Index Of Refraction | 1.574 |
| In Vitro | 3,4-Dimethoxycinnamic acid (Methyl ferulic acid; 25, 50 and 100 µM) attenuates the ethanol-induced Apoptosis of ethanolexposed L-02 cells. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) inhibits the expression levels of Nox4 and p22phox in L-02 cells. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) treatment attenuates ethanol-induced MAPK phosphorylation in L-02 cells. 3,4-Dimethoxycinnamic acid decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase, and downregulates the levels of Bax/Bcl-2 and the cleaved forms of Caspase-3 in a dose- and time-dependent manner. |
| PSA | 55.76000 |
| Target | Reactive Oxygen Species; Virus Protease |
| Vapor Pressure | 0.0±0.9 mmHg at 25°C |
| XLogP3-AA | 1.8 |
