3,4-Di(3-indolyl)-1H-pyrrole-2,5-dione

Category	Cytomegalovirus (CMV)
CAS	119139-23-0
Description	Bisindolylmaleimide IV (BIM IV) is an inhibitor of pyruvate phosphate dikinase (PPDK). It is a cell-permeable potent and somewhat selective inhibitor of PKC with IC50 of 87 nM. BIM IV is a cell-permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 µM. It also inhibits protein kinase A (PKA) with an IC50 of 2.7 μM.

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Synonyms	3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione; 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione
IUPAC Name	3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione
Molecular Weight	327.34
Molecular Formula	C20H13N3O2
Canonical SMILES	C1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
InChI	InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
InChIKey	DQYBRTASHMYDJG-UHFFFAOYSA-N
Boiling Point	690.1 °C at 760 mmHg (Predicted)
Melting Point	296.19 °C (Predicted)
Flash Point	371.2±31.5 °C
Purity	> 98 %
Density	1.486 g/cm³
Solubility	Soluble in DMSO.
Appearance	Crystalline solid
Storage	Powder: -20°C 3 years 4°C 2 years In solvent: -80°C 6 months -20°C 1 months
Complexity	576
Exact Mass	327.100776666
Index Of Refraction	1.811
In Vitro	The IC50 of biindolecarboximide IV (Arcyriarubin A) in 1% dimethyl sulfoxide is 0.1 μM and the IC50 in 10% dimethyl sulfoxide is 0.55 μM, which has an inhibitory effect on PKC.
PSA	77.75000
Target	PKC; CMV
Vapor Pressure	0.0±2.2 mmHg at 25°C
XLogP3-AA	2.8