-
Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
2'-Deoxy-5'-O-DMT-2'-fluoro-uridine
Category | Influenza Virus |
CAS | 146954-74-7 |
Description | It is used for RNA synthesis and nucleoside modification. |
Product Information
Synonyms | 2'-F-5'-O-DMT-2'-dU; 5'-O-DMT-2'-fluoro-2'-deoxy-D-uridine; 2'-Fluoro-5'-O-DMT-uridine; 2'-Deoxy-5'-O-DMT-2'-fluoro-D-uridine; 5'-O-DMT-2'-fluoro-2'-deoxyuridine; 1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 5'-O-DMTr-2'-F-dU |
IUPAC Name | 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione |
Molecular Weight | 548.56 |
Molecular Formula | C30H29FN2O7 |
Canonical SMILES | COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=CC(=O)NC5=O)F)O |
InChI | InChI=1S/C30H29FN2O7/c1-37-22-12-8-20(9-13-22)30(19-6-4-3-5-7-19,21-10-14-23(38-2)15-11-21)39-18-24-27(35)26(31)28(40-24)33-17-16-25(34)32-29(33)36/h3-17,24,26-28,35H,18H2,1-2H3,(H,32,34,36)/t24-,26-,27-,28-/m1/s1 |
InChIKey | CSSFZSSZXOCCJB-YULOIDQLSA-N |
Purity | ≥95% |
Density | 1.38±0.1 g/cm3(Predicted) |
Solubility | Soluble in DMSO (10 mM) |
Appearance | White to Off-white Crystalline Powder |
Storage | Store at -20°C |
Complexity | 873 |
Exact Mass | 851.34600 |
In Vitro | 2'-Deoxy-5'-O-DMT-2'-fluorouridine (compound 15h) has 100% inhibition against YFV at 20 mM, and it proves to be noncytotoxic at concen-trations up to 20 mM. |
PSA | 159.99000 |
Target | Filovirus |
XLogP3-AA | 3.6 |