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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
2'-Deoxy-2'-fluorocytidine
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| Category | Influenza Virus |
| CAS | 10212-20-1 |
| Description | 2'-Deoxy-2'-fluorocytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Deoxy-2'-fluorocytidine demonstrated to inhibit Borna Disease virus replication and spread. |
Product Information
| Synonyms | 2'-Fluoro Cytidine; 2'-Fluoro-2'-deoxy-β-D-ribofuranosylcytosine; 2'-Fluoro-2'-deoxycytidine; NSC 529432; 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 2'-F-dC |
| IUPAC Name | 4-amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
| Molecular Weight | 245.21 |
| Molecular Formula | C9H12FN3O4 |
| Canonical SMILES | C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)F |
| InChI | InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1 |
| InChIKey | NVZFZMCNALTPBY-XVFCMESISA-N |
| Boiling Point | 500.1±60.0°C (Predicted) |
| Melting Point | >187°C (dec.) |
| Purity | ≥95% |
| Density | 1.82±0.1 g/cm3 (Predicted) |
| Solubility | Soluble in DMSO (Slightly), Methanol (Slightly) |
| Appearance | White Solid |
| Storage | Store at 2-8°C |
| Complexity | 386 |
| Exact Mass | 349.107391 |
| Index Of Refraction | 1.669 |
| In Vitro | 2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells. |
| PSA | 113.68000 |
| Target | Influenza Virus: Crimean-Congo hemorrhagic fever virus (CCHFV) |
| XLogP3-AA | -1.1 |
