2'-C-methyladenosine

Category	Hepatitis C Virus (HCV)
CAS	15397-12-3
Description	2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication (IC50 = 0.3 µM in Huh-7 human hepatoma cells) that is not cytotoxic at concentrations up to 100 µM.

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Synonyms	2'-C-methyladenosine;15397-12-3;(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol;2'-methyl-adenosine;2-C-methyl adenosine;(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol;CHEMBL73809;2''-C-methyladenosine;2/'-C-Methyladenosine;(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol;2-c-methyladenosine;2''-methyl-adenosine;2'-C-Methyl-adenosine;2'-C-Methyl Adenosine;Beta-2'-Methyladenosine;beta-2''-Methyladenosine;2'-C-MeA;SCHEMBL382543;2'-C-Me-A;DTXSID90333334;PASOFFRBGIVJET-YRKGHMEHSA-N;2'-C-CH3-A;BCX-4026;BDBM50144948;MFCD02682944;AKOS015914550;BS-25234;DA-49398;PD077382;F12904;(3R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol;(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol;(2R,3R,4R,5R)-5-Hydroxymethyl-3-methyl-2-(6-methylamino-purin-9-yl)-tetrahydro-furan-3,4-diol;
IUPAC Name	(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
Molecular Weight	281.27
Molecular Formula	C11H15N5O4
Canonical SMILES	OC[C@@H]1[C@@H](O)[C@@](C)(O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1
InChI	InChI=1S/C11H15N5O4/c1-11(19)7(18)5(2-17)20-10(11)16-4-15-6-8(12)13-3-14-9(6)16/h3-5,7,10,17-19H,2H2,1H3,(H2,12,13,14)/t5-,7-,10-,11-/m1/s1
InChIKey	PASOFFRBGIVJET-YRKGHMEHSA-N
Boiling Point	643.4±65.0 °C at 760 mmHg
Purity	≥95%
Density	1.89±0.1 g/cm3
Solubility	Soluble in DMF, DMSO, PBS
Appearance	Solid
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)