1-Adamantanamine sulfate

Category	Influenza Virus
CAS	31377-23-8
Description	Amantadine (1-Adamantanamine) sulfate is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine sulfate inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. It also has anti-orthopoxvirus and anticancer activity. Amantadine sulfate can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research.

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Synonyms	ADAMANTYLAMINE SULFATE; AMANTADINE SULFATE; AMANTADINE SULPHATE; 1-AMINOADAMANTANE SULFATE; 1-AMINOADAMANTANE SULPHATE; 1-AMINOADAMANTANSULFATE
IUPAC Name	adamantan-1-amine;sulfuric acid
Molecular Weight	249.32
Molecular Formula	C10H17N.H2SO4
Canonical SMILES	C1C2CC3CC1CC(C2)(C3)N.OS(=O)(=O)O
InChI	InChI=1S/C10H17N.H2O4S/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;1-5(2,3)4/h7-9H,1-6,11H2;(H2,1,2,3,4)
InChIKey	PLRGINNCKYSSTP-UHFFFAOYSA-N
Boiling Point	225.7°C at 760 mmHg
Melting Point	300°C
Flash Point	96°C
Purity	96.0%
Density	1.066g/cm3
Solubility	In vitro: 10 mM in DMSO
Appearance	white fine crystalline powder
Storage	Store below +30°C.
Complexity	225
Exact Mass	400.239563
In Vitro	Amantadine-sulfate caused a concentration-dependent reduction (IC50=83 µM) of viral nucleic acids in the supernatant 26 h after infection at 10-500 µM. Caused a concentration-dependent reduction (IC50=119 µM) of viral nucleic acids in the cytosol 26 h after infection.
In Vivo	Amantadine-sulfate inhibited surgery induced neuroinflammation and learning and memory impairment, increased GDNF (glial cell line-derived neurotrophic factor) that was co-localized with glial fibrillary acidic protein (an astrocytic marker) in the hippocampus.
PSA	135.02000
Target	Influenza Virus; Orthopoxvirus; SARS-CoV; Apoptosis; CDK; Bcl-2 Family