Mefloquine

Category	SARS-CoV
CAS	53230-10-7
Description	Mefloquine is, a quinoline methanol phospholipid-interacting antimalarial drug, is very effective against sensitive malaria parasites with few side effects. Mefloquine may cause vomiting, especially in children.

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Synonyms	mefloquine;53230-10-7;(-)-Mefloquine;Mefloquin;Mefloquina;Mefloquinum;Mefloquinum [INN-Latin];Mefloquina [INN-Spanish];Ro 21-5998;(-)-(11S,2'R)-erythro-Mefloquine;Ro 215998;HSDB 6853;Racemic mefloquine;WR 142490;51742-87-1;UNII-TML814419R;TML814419R;(S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2R)-piperidin-2-yl]methanol;Mephloquine;CHEMBL172;(DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol;DTXSID4037168;CHEBI:63687;(S)-[2,8-bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol;4-Quinolinemethanol, alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-, (R,S)-(+-)-;(+)-(11S,2'R)-erythro-Mefloquine;NSC 758233;Ro-215998;Mefloquinum (INN-Latin);Mefloquina (INN-Spanish);(S)-(2,8-bis(trifluoromethyl)quinolin-4-yl)((R)-piperidin-2-yl)methanol;4-Quinolinemethanol, a-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-,(aS)-rel-;RTI1189-1-1;4-Quinolinemethanol, alpha-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, (alphaS)-rel-;RO 13-7225;WR 142,490;Mefloquine [USAN:INN:BAN];MLS001332559;[(11S,2'R)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol;NSC-758233;4-Quinolinemethanol, alpha-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, (alphaS)-;(S,R)-MEFLOQUINE;NCGC00161831-02;Mefloquine (USAN/INN);SMR000875233;Mephaquine;(S)-[2,8-bis(trifluoromethyl)-4-quinolyl]-[(2R)-2-piperidyl]methanol;Mefloquinum (Latin);Mefloquine, (+)-;MEFLOQUINE [MI];(-)-erythro-Mefloquine;MEFLOQUINE [INN];MEFLOQUINE [HSDB];MEFLOQUINE [USAN];MEFLOQUINE [VANDF];MEFLOQUINE [WHO-DD];BIDD:PXR0166;SCHEMBL21780;cid_65329;BIDD:GT0596;((R,S)-2,8-bis(trifluoromethyl)quinolin-4-yl)-(2-piperidyl)methanol;BDBM79170;CHEBI:63609;P01BC02;(DL-erythro-.alpha.-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol;4-Quinolinemethanol, alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-, (R,S)-(+/-)-;XEEQGYMUWCZPDN-DOMZBBRYSA-N;5G5QQ725P9;DTXCID001473959;DTXSID101019853;BDBM50151865;MMV000014;MMV000016;NSC790109;AKOS040732205;NSC-790109;NCGC00161831-01;NCGC00161831-03;DA-65319;HY-17437;TS-07649;CS-0007927;C07633;D04895;BRD-K40645748-003-08-5;Q27084116;(+)-erythro-4-Quinolinemethanol, .alpha.-2-piperidinyl-2,8-bis(trifluoromethyl)-;(alphaS)-alpha-(2R)-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol;(DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl))-4-quinolinemethanol;(S)-[2,8-bis(trifluoromethyl)-4-quinolinyl]-[(2R)-2-piperidinyl]methanol;hydrochloride;(S)-[2,8-bis(trifluoromethyl)-4-quinolyl]-[(2R)-2-piperidyl]methanol;hydrochloride;4-Quinolinemethanol, .alpha.-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, (.alpha.S)-;rac--(R)-(2,8-bis(trifluoromethyl)quinolin-4-yl)((2S)-piperidin-2-yl)methanol;rel-(alphaS)-alpha-(2R)-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol;147368-41-0;4-Quinolinemethanol, .alpha.-[(2R)-2-piperidinyl]-2,8-bis(trifluoromethyl)-, (.alpha.S)-, rel-;4-QUINOLINEMETHANOL, .ALPHA.-2-PIPERIDINYL-2,8-BIS(TRIFLUOROMETHYL)-, (R,S)-(+/-)-;
IUPAC Name	(S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2R)-piperidin-2-yl]methanol
Molecular Weight	441.5
Molecular Formula	C26H27N5O2
Canonical SMILES	CN1CCN(CC1)C2=CC=CC(=C2)NC3=NC=C4C=C(C(=O)N(C4=C3)C)C5=CC(=CC=C5)O
InChI	InChI=1S/C17H16F6N2O/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11/h3-5,8,12,15,24,26H,1-2,6-7H2/t12-,15+/m1/s1
InChIKey	XEEQGYMUWCZPDN-DOMZBBRYSA-N
Melting Point	174-176 °C
Density	1.432 g/cm3
Solubility	Soluble to 6.212 mg/L in DMSO at 25 °C (est.)
Application	Treating or preventing malaria
Shelf Life	2 years
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.