Filgotinib

Category	Human immunodeficiency Virus (HIV)
CAS	1206161-97-8
Description	Filgotinib is a potent and selective JAK1 inhibitor exhibiting 30-fold selectivity over JAK2. It was shown to inhibit Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro. Filgotinib has the potential for the treatment of rheumatoid arthritis and possibly other immune-inflammatory diseases.

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Product Information

Synonyms	1206101-20-3;Filgotinib;GLPG0634;1206161-97-8;GLPG-0634;N-(5-(4-((1,1-dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide;Filgotinib (GLPG0634);N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide;Filgotinib(GLPG0634);GS-6034 FREE BASE;3XVL385Q0M;N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide;G146034;G-146034;Jyseleca;Filgotinib [INN];N-(5-(4-((1,1-dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide.;Filgotinib [USAN:INN];UNII-3XVL385Q0M;GLPG 0634;N-(5-{4-[(1,1-Dioxidothiomorpholin-4-Yl)methyl]phenyl}[1,2,4]triazolo[1,5-A]pyridin-2-Yl)cyclopropanecarboxamide;Filgotinib (USAN/INN);FILGOTINIB [USAN];Filgotinib; GPLG0634;Filgotinib(GLPG0634)?;FILGOTINIB [WHO-DD];SCHEMBL253559;Filgotinib pound GLPG0643);GTPL7913;CHEMBL3301607;AMY3802;DTXSID80152935;EX-A741;BDBM103727;HMS3653P15;HMS3673E07;BCP08496;MFCD20527867;NSC800100;s7605;AKOS025291103;CCG-268951;DB14845;NSC-800100;SB16799;NCGC00345855-01;NCGC00345855-07;AS-16295;BF159062;DA-33603;DA-33604;HY-18300;SW220020-1;D10871;P12798;US8563545, 1;EN300-7419864;A892158;J-690063;SYN1158;GLPG 0634; GLPG-0634; Filgotinib;BRD-K16803204-001-01-6;Q19904163;Z2037280227;CYCLOPROPANECARBOXAMIDE, N-(5-(4-((1,1-DIOXIDO-4-THIOMORPHOLINYL)METHYL)PHENYL)(1,2,4)TRIAZOLO(1,5-A)PYRIDIN-2-YL)-;GLPG0634;N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide;N-(5-(4-((1,1-OXO-.LAMBDA.6-THIOMORPHOLIN-4-YL)METHYL)PHENYL((1,2,4)TRIAZOLO(1,5-A)PYRIDIN-2-YL)CYCLOPROPANECARBOXAMIDE;N-(5-{4-[(1,1-dioxo-1lambda6-thiomorpholin-4-yl)methyl]phenyl}-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide;N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl] cyclopropanecarboxa;
IUPAC Name	N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide
Molecular Weight	425.50
Molecular Formula	C21H23N5O3S
Canonical SMILES	O=C(C1CC1)NC2=NN3C(C4=CC=C(CN5CCS(CC5)(=O)=O)C=C4)=CC=CC3=N2
InChI	InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
InChIKey	RIJLVEAXPNLDTC-UHFFFAOYSA-N
Purity	>98%
Appearance	Solid