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Antiviral API
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Clemizole
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| Category | HCV Protease |
| CAS | 442-52-4 |
| Description | Clemizole is an H1 antagonist acts as a TRPC5 channel blocker (IC50 values are 1.1, 6.4, 9.1, 11.3 and 26.5 μM for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). |
Product Information
| Synonyms | Clemizole;442-52-4;Histacur;Clemizol;Histakool;1-(4-Chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole;Clemizolum;Lergopenin;Depocural;1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole;1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole;1-p-Chlorobenzyl-2-(1-pyrrolidinylmethyl)benzimidazole;NSC 46261;NSC-46261;AL-20 FREE BASE;CHEBI:52140;T97CB3796L;AL 20 [AS HYDROCHLORIDE];1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-;Benzimidazole, 1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-;1H-Benzimidazole, 1-((4-chlorophenyl)methyl)-2-(1-pyrrolidinylmethyl)-;Clemizolo;1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole;C19H20ClN3;Clemizolo [DCIT];Clemizole [INN:BAN];NCGC00015243-02;Clemizol [INN-Spanish];Clemizolum [INN-Latin];CAS-1163-36-6;UNII-T97CB3796L;EINECS 207-133-5;Clemizole (free base);CLEMIZOLE [INN];Clemizole (free base)?;CLEMIZOLE [MI];Prestwick0_000227;Prestwick1_000227;Prestwick2_000227;Prestwick3_000227;Lopac-C-5040;CLEMIZOLE [WHO-DD];Lopac0_000284;Oprea1_226569;SCHEMBL29938;BSPBio_000273;SPBio_002194;BPBio1_000301;CHEMBL1407943;DTXSID0046939;BDBM85747;GTPL10285;BCP07894;NSC_2782;NSC46261;1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole;MFCD00051434;s6410;AKOS001631429;CCG-106577;CS-1481;SDCCGSBI-0050272.P003;NCGC00015243-01;NCGC00015243-03;NCGC00015243-04;NCGC00015243-05;NCGC00015243-06;NCGC00015243-07;NCGC00015243-11;NCGC00015243-20;NCGC00015243-21;NCGC00024376-03;AS-56130;CAS_442-52-4;DA-51956;HY-30234;SBI-0050272.P002;NS00005706;L000853;Q5131527;SR-01000000057-6;SR-01000000057-9;BRD-K04704168-003-03-6;BRD-K04704168-003-11-9;BRD-K04704168-003-14-3;F0902-3266;1-(4-CHLOROBENZYL)-2-PYRROLIDINOMETHYL-BENZIMIDAZOLE;Pyrrolidine, 1-[(1-p-chlorobenzyl-2-benzimidazolyl)methyl]-;1-(4-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole #;1-[(4-Chlorophenyl)methyl]-2-(pyrrolidinylmethyl)-1H-benzimidazole;GX0; |
| IUPAC Name | 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole |
| Molecular Weight | 325.84 |
| Molecular Formula | C19H20ClN3 |
| Canonical SMILES | ClC1=CC=C(C=C1)CN2C(CN3CCCC3)=NC4=CC=CC=C24 |
| InChI | InChI=1S/C19H20ClN3/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22/h1-2,5-10H,3-4,11-14H2 |
| InChIKey | CJXAEXPPLWQRFR-UHFFFAOYSA-N |
| Boiling Point | 506.1°C at 760mmHg |
| Purity | ≥95% |
| Density | 1.25 g/cm3 |
| Solubility | Soluble in DMSO |
| Appearance | Solid |
| Application | TRPC5 channel blocker |
| Shelf Life | As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
